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Arajo P, Wassermann GF, Tallini K, Furlanetto V, Vargas CR, Wannmacher CM et al (2001) Reduction of large neutral amino acid levels in plasma and brain of hyperleucinemic rats

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Instead of continuing full therapeutic doses, many patients transition to lower or maintenance doses under medical supervision

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This interaction is particularly relevant in the context of cancer biology, where COP1 has been implicated in tumor suppression by regulating transcription factors like c-Jun and oncogenic pathways